Why the study?
Does a pathophysiological increase in plasma endothelin concentration alter long-term systemic hemodynamics and renal function in conscious dogs?
Population
Chronically instrumented, conscious dogs (n=7)
Comparison
Infusion of endothelin-1 for 8 days vs Baseline control values
Design
Preclinical
Follow-up
8 days
Authors
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Endothelin-1 sustains hypertension in dogs; leaves open its causal role in human chronic hypertension pending clinical studies.
Does a pathophysiological increase in plasma endothelin concentration alter long-term systemic hemodynamics and renal function in conscious dogs?
Pathophysiological increases in circulating endothelin-1 lead to sustained hypertension, increased peripheral resistance, and decreased cardiac output and renal function, suggesting its role as a mediator of chronic hypertension.
Wilkins et al. (1995) studied this question.
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