Why the study?
Does endothelin-1 infusion affect glomerular hydraulic pressure and renin release in a canine nonfiltering kidney model?
Population
Canine nonfiltering kidney model
Comparison
Intrarenal infusion of endothelin-1 at various… vs Control level (baseline)
Design
Preclinical
Authors
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Endothelin-1 shows dose-dependent renal effects in canines; leaves open translation to human glomerular and renin regulation in hypertension.
Does endothelin-1 infusion affect glomerular hydraulic pressure and renin release in a canine nonfiltering kidney model?
Endothelin-1 exerts dose-dependent effects on preglomerular and postglomerular resistances, reducing renal blood flow and renin release, while only reducing glomerular hydraulic pressure at high doses.
Lin et al. (1993) studied this question.
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