December 1, 1990Clinical and Experimental Pharmacology and Physiology
Vascular Actions of Endothelin in the Rabbit Kidney
Population
Anaesthetized rabbits
Comparison
Endothelin infusion at 10 and 50 ng/kg per min… vs Vehicle infusion
Design
Preclinical
Follow-up
90 minutes
Authors
Discussion
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Implication
Endothelin-driven renal vasoconstriction in rabbits is hypothesis-generating; leaves open translation to human glomerular disease.
Structured PICO
P
Population
Anaesthetized rabbits
I
Intervention
Endothelin infusion at 10 and 50 ng/kg per min, i.v., for up to 90 minutes
C
Comparator
Vehicle infusion
O
Outcome
Glomerular filtration rate (GFR), tubular stop flow pressure, and pre- and post-glomerular vascular resistancesurrogate
Endothelin causes significant and progressive renal vasoconstriction in both pre- and postglomerular vessels in rabbits, independent of systemic blood pressure changes.
Cite This Study
Denton et al. (1990) studied this question.