January 1, 1996Clinical and Experimental Hypertension
Endothelin-1 Produces Heterogeneous Regional Haemodynamic Effects in Conscious Rabbits
Why the study?
What are the regional haemodynamic effects of intravenous endothelin-1 in conscious rabbits, and what pathways mediate these effects?
Population
Conscious rabbits (n=27)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
NO mediates ET-1 hindlimb vasodilatation in rabbits; leaves open translation to human cardiovascular therapy.
Structured PICO
What are the regional haemodynamic effects of intravenous endothelin-1 in conscious rabbits, and what pathways mediate these effects?
P
Population
Conscious rabbits (n=27)
I
Intervention
Intravenous endothelin-1 (0.2 and 0.8 nmol/kg) alone and with antagonists (phentolamine, propranolol, scopolamine, captopril, nifedipine, indomethacin, V1-vasopressin receptor antagonist, NOLA)
O
Outcome
Arterial pressure, heart rate, and blood flow/resistance in renal, mesenteric, and hindlimb arteriessurrogate
Endothelin-1 produces heterogeneous regional haemodynamic effects in conscious rabbits, with hindlimb vasodilatation partially mediated by nitric oxide.
Cite This Study
Roberts-Thomson et al. (1996) studied this question.