Why the study?
Does an intravenous bolus of endothelin-1 affect arterial pressure and myocardial contractility in conscious normotensive rabbits?
Does an intravenous bolus of endothelin-1 affect arterial pressure and myocardial contractility in conscious normotensive rabbits?
Endothelin-1 induces a biphasic blood pressure response and generally increases myocardial contractility except at high doses in conscious rabbits.
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Preclinical rabbit data warrant no clinical change; leaves open translation of endothelin-1 effects to conscious models.
We studied the effects of an intravenous bolus of endothelin-1 on arterial pressure and myocardial contractility in the conscious rabbit. 2. Endothelin produced an initial fall in arterial pressure accompanied by an increase in heart rate. This was followed by a dose-dependent increase in arterial pressure, peaking about 7 min after injection, accompanied by a reciprocal fall in heart rate. 3. Left ventricular rate of change of pressure (LV dP dt) increased with endothelin except at higher doses (0.8 and 1.6 nmol/kg), where in some animals it decreased.
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Roberts-Thomson et al. (1991) studied this question.
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