Key result
Endothelin (1-10 nmol/L) produced paradoxical effects, reducing vasoconstrictor and chronotropic responses to sympathetic nerve stimulation while increasing stimulation-induced noradrenaline release.
Why the study?
Does endothelin modulate cardiovascular noradrenergic neurotransmission in isolated arterial and atrial preparations?
Does endothelin modulate cardiovascular noradrenergic neurotransmission in isolated arterial and atrial preparations?
Endothelin demonstrates complex, paradoxical pre- and postjunctional effects on noradrenergic neurotransmission in cardiovascular tissues, persisting even after its removal.
Answers are grounded in this paper and cite their sources.
Complex effects on sympathetic neurotransmission in isolated tissues; hypothesis-generating and leaves open net cardiovascular impact in vivo.
Pre- and postjunctional effects of endothelin (1-10 nmol/L) have been studied in the rabbit isolated ear artery and in rat isolated atria. 2. Endothelin produced concentration-dependent increases in arterial perfusion pressure, and had positive chronotropic and inotropic effects in rat atria. 3. Vasoconstrictor responses of the arteries to sympathetic nerve stimulation were reduced by 1 nmol/L endothelin and abolished by 10 nmol/L endothelin. In rat atria, the chronotropic responses to nerve stimulation were markedly reduced by 10 nmol/L endothelin. 4. In rabbit ear artery, vasoconstrictor responses to noradrenaline were enhanced by 1 nmol/L endothelin, but were reduced by 10 nmol/L endothelin. In rat atria, endothelin reduced the chronotropic response to isoprenaline. 5. Endothelin (10 nmol/L) increased the stimulation-induced release of radioactivity in arteries and atria labelled with [3H]-noradrenaline by 91% and 23%, respectively. 6. The pre- and postjunctional effects of endothelin persisted in both arterial and atrial preparations for at least 30 min after its removal.
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Wong‐Dusting et al. (1989) studied this question. Endothelin was evaluated on Pre- and postjunctional effects on cardiovascular noradrenergic neurotransmission. Endothelin (1-10 nmol/L) produced paradoxical effects, reducing vasoconstrictor and chronotropic responses to sympathetic nerve stimulation while increasing stimulation-induced noradrenaline release.
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