Key result
Endothelin produced a concentration-dependent increase in cardiac output in isolated rat hearts, with high concentrations (600 pmol/l) causing subsequent severe coronary vasoconstriction.
Why the study?
Does endothelin affect cardiac output and coronary vascular resistance in the isolated perfused working rat heart?
Population
Isolated perfused working rat heart
Comparison
Endothelin at low and high concentrations, with… vs Baseline or hearts not exposed to calcium-entry…
Design
Preclinical
Authors
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Endothelin shows concentration-dependent effects on rat heart output and coronary tone; leaves open translation to human physiology or therapy.
Does endothelin affect cardiac output and coronary vascular resistance in the isolated perfused working rat heart?
Endothelin exerts distinct, concentration-dependent effects on myocardial contractility and coronary vasculature in the isolated rat heart, suggesting different underlying mechanisms.
Firth et al. (1990) studied Isolated perfused working rat heart. Endothelin was evaluated on Cardiac output and coronary vascular resistance. Endothelin produced a concentration-dependent increase in cardiac output in isolated rat hearts, with high concentrations (600 pmol/l) causing subsequent severe coronary vasoconstriction.
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