Why the study?
Does endothelin-1 cause vasodilation in the isolated perfused rat heart, and is it mediated by PGI2 or EDRF?
Does endothelin-1 cause vasodilation in the isolated perfused rat heart, and is it mediated by PGI2 or EDRF?
Endothelin-1 exhibits a transient, dose-dependent vasodilator effect in the rat heart that precedes vasoconstriction and appears independent of prostacyclin and EDRF.
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May inform experimental models of cardiac vasoregulation; leaves open translation to human disease or therapy.
Baydoun et al. (1990) studied this question.