Key result
Endothelin-1 and endothelin-3 caused dose-dependent increases in coronary perfusion pressure that were mediated by both ETA and ETB receptors in the perfused rat heart.
Population
Langendorff perfused rat heart model
Design
Preclinical
Authors
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ETB mediation of coronary vasoconstriction indicated in vitro; leaves open relevance to human disease and therapy.
Both ETA and ETB receptor subtypes mediate endothelin-induced coronary vasoconstriction in the rat heart.
Joseph L. Balwierczak (1993) studied this question. Endothelin-1 and Endothelin-3 was evaluated on Coronary perfusion pressure. Endothelin-1 and endothelin-3 caused dose-dependent increases in coronary perfusion pressure that were mediated by both ETA and ETB receptors in the perfused rat heart.
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