July 1, 1996AJP Regulatory Integrative and Comparative Physiology

Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat

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Population

Conscious Sprague-Dawley rats

Comparison

Intravenous administration of endothelin… vs Basal state or alternative antagonists

Design

Preclinical

Authors

MGM. GellaiNew Frontier TFTracey FletcherRoyal Victoria Regional Health Centre MPM PullenRadboud University Nijmegen

Discussion

Member takes

Implication

Distinguishes opposing ETB subtypes in rat vessels; leaves open translation to human endothelin pathways.

Structured PICO

Population

Conscious Sprague-Dawley rats

Intervention

Intravenous administration of endothelin receptor agonists and antagonists (sarafotoxin 6c, RES-701-1, SB-209670, BQ-123)

Comparator

Basal state or alternative antagonists

Outcome

Mean arterial pressure, hindlimb flow, and renal blood flowsurrogate

Endothelin-B receptors in rats consist of two subtypes with opposing vascular effects, with endogenous endothelin predominantly mediating vasodilation.

Cite This Study

Gellai et al. (1996) studied this question.

synapsesocial.com/papers/6a8309bf1557c09efd7d5a58 https://doi.org/10.1152/ajpregu.1996.271.1.r254

View Full Paper

Ask AI

Bookmark

Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence for the existence of endothelin-B receptor subtypes and their physiological roles in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider