Population
Isolated perfused rat kidneys and anaesthetized rats
Comparison
Endothelin-1, sarafotoxin 6b, and sarafotoxin 6c… vs Agonists alone versus pretreatment with…
Design
Preclinical
Authors
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Animal data implicate ETB predominance in renal vasoconstriction; leaves open whether dual antagonists confer superior protection in humans.
ETB receptors play a predominant role in endothelin-induced renal vasoconstriction in vivo, suggesting non-selective antagonists may be required for full renal protection.
Wellings et al. (1994) studied this question.
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