June 1, 1997Journal of Cardiovascular Pharmacology

Cardiovascular and Renal Actions of the EndothelinB Receptor in Pigs

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Population

Anesthetized pigs (n=9)

Comparison

BQ-788 (selective ET receptor antagonist, 1.0… vs Baseline or Endothelin-1 alone

Design

Preclinical

Authors

MCM. CirinoGuarulhos University MMM. Elena Martı́nInstituto Ramón y Cajal de Investigación Sanitaria MYM. YanoUniversité de Sherbrooke

Discussion

Member takes

Implication

ETB antagonism differentially modulates ET-1 vascular responses in pigs; leaves open translation to human endothelin-targeted therapies.

Structured PICO

Population

Anesthetized pigs (n=9)

Intervention

BQ-788 (selective ET(B) receptor antagonist, 1.0 mg/kg i.v.), sarafotoxin S6c (selective ET(B) agonist), and Endothelin-1 (0.4 nmol/kg i.v.)

Comparator

Baseline or Endothelin-1 alone

Outcome

Hemodynamic responses including mean arterial pressure, cardiac output, myocardial contractility, and renal blood flowsurrogate

The ET(B) receptor mediates the transient vasodilation provoked by ET-1 and appears to oppose the vasoconstrictor effects of the ET(A) receptor in a porcine model.

Cite This Study

Cirino et al. (1997) studied this question.

synapsesocial.com/papers/6a72f594e188acf788cf2bd7 https://doi.org/10.1097/00005344-199706000-00002

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Cardiovascular and Renal Actions of the EndothelinB Receptor in Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiovascular and Renal Actions of the EndothelinB Receptor in Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider