Why the study?
Does BQ-153 inhibit the renal vascular effects of endothelin-1 in anaesthetized pigs?
Population
Anaesthetized pigs
Design
Preclinical
Authors
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May inform selective ETA antagonist development; hypothesis-generating for human renal vascular disease.
Does BQ-153 inhibit the renal vascular effects of endothelin-1 in anaesthetized pigs?
The selective ETA antagonist BQ-153 dose-dependently inhibits the vasoconstrictor, but not the vasodilator, renal vascular effects of endothelin-1 in pigs.
Cirino et al. (1992) studied this question.
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