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July 1, 1998British Journal of PharmacologyOpen Access

Systemic and renal effects of an ETA receptor subtype‐specific antagonist in healthy subjects

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Why the study?

Does BQ-123 prevent ET-1 induced reductions in renal plasma flow and glomerular filtration rate in healthy male subjects?

Population

10 healthy male subjects

Comparison

BQ-123 co-infused with ET-1 or placebo vs Placebo co-infused with ET-1 or placebo

Design

RCT, balanced, randomized, 4 way cross-over design, double blind…

Follow-up

120 minutes

Authors

LSLeopold SchmettererNanyang Technological UniversitySDSusanne DallingerUniversity of ViennaBBBarbara BobrVienna General Hospital

Discussion

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Implication

ETA blockade may preserve renal hemodynamics in ET-1 excess states; confirms predominant ETA mediation and supports targeted trials.

Structured PICO

Does BQ-123 prevent ET-1 induced reductions in renal plasma flow and glomerular filtration rate in healthy male subjects?

P
Population
10 healthy male subjects
I
Intervention
BQ-123 (15 microg/min for 60 min and subsequently 60 microg/min for 60 min) co-infused with ET-1 (2.5 ng/kg/min for 120 min) or placebo
C
Comparator
Placebo co-infused with ET-1 or placebo
O
Outcome
Renal plasma flow (RPF) and glomerular filtration rate (GFR)surrogate

The ETA receptor antagonist BQ-123 reverses renal vasoconstriction induced by exogenous ET-1 in healthy subjects, demonstrating that ET-1 mediated renal vasoconstriction is predominantly driven by the ETA receptor subtype.

Cite This Study

Schmetterer et al. (1998) studied this question.

synapsesocial.com/papers/6a760f4949a8cdd61fb1eecdhttps://doi.org/10.1038/sj.bjp.0701923
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of ETB Receptors Limits the Efficacy of Nonselective Endothelin Antagonists In Vivo1995 · 9 citations
  2. 2Dose‐ and time‐dependency of the dilator effects of the endothelin antagonist, BQ‐123, in the human forearm1997 · 40 citations
  3. 3Regional Hemodynamic Effects and Clearance of Endothelin-1 in Humans1992 · 71 citations
  4. 4Endothelin ET A and ET B Receptors Cause Vasoconstriction of Human Resistance and Capacitance Vessels In Vivo1995 · 281 citations
  5. 5Endothelins as Regulators of Vascular Tone in Man1995 · 51 citations