Population
Anaesthetized Sprague-Dawley rats
Comparison
BQ-123 co-infused with either big ET-1 or ET-1… vs Infusion of big ET-1 or ET-1 alone
Design
Preclinical
Follow-up
60 min
Authors
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ETA blockade prevents ET-1 renal effects in rats; leaves open translation to human cardiorenal disease and requires clinical trials.
In the rat kidney, moderately low doses of ET-1 and big ET-1 produce renal vasoconstriction primarily via ETA receptors, which can be completely blocked by BQ-123.
Pollock et al. (1994) studied this question.
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