Discovery Laboratories (United States)

Recent papers from Discovery Laboratories (United States)

1. The Clinical Utility of Adding Laminin Gamma 2 Monomer to the PAGE‐B Score for Hepatocellular Carcinoma Surveillance in Chronic Hepatitis BJournal of Gastroenterology and Hepatology · 2026
2. Targeted mRNA Delivery Using Bispecific Antibody-Lipid Nanoparticle ComplexesMolecular Pharmaceutics · 2026
3. Black turmeric (Curcuma caesia) derived biogenic carbon nanodots: green synthesis, characterization, in vitro antioxidant potential, bio-evaluation studies, and photocatalytic degradation of Rhodamine-BFullerenes Nanotubes and Carbon Nanostructures · 2026
4. Investigation of a metabolism-dependent aryl hydrocarbon receptor off-target activation for a drug development candidate and a screening strategy for de-risking backupsToxicological Sciences · 2026
5. Phosphatidylinositol diphosphate binding by ESCRT-III filamentsProceedings of the National Academy of Sciences · 2026
6. Weekend-free and robotics-compatible protocols for high-throughput human-induced pluripotent stem cell maintenance, amplification, and differentiationStem Cells Translational Medicine · 2026
7. Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulationNeuroscience Letters · 2026
8. Clinical Practice and Treatment Satisfaction among Patients with Tinnitus in Japan: A Cross-Sectional Web SurveyNippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) · 2026
9. Drug Delivery Strategy Exploiting Amino Acid Prodrugs: Improving Oral Bioavailability and Overcoming Nonlinear Pharmacokinetic Challenges Following Dose Escalation of a CK2 Inhibitor with Poor SolubilityJournal of Medicinal Chemistry · 2026
10. Mast cell proteases and their significance in physiology, pathology, and therapeutic approachesPharmacological Reviews · 2026
11. Protein Homeostasis Screen Identifies CK2 Inhibition as a Driver of CARD9 DepletionACS Chemical Biology · 2026
12. Direct Access to Iron Carbenes from Aldehyde, Ketone, and Formamide FeedstocksJournal of the American Chemical Society · 2026
13. A Novel PTPN2 Isoform Differentially Regulates Immune ResponseEuropean Journal of Immunology · 2026
14. Discovery of MK-5661, a Once-Daily Oral Na V 1.8 Inhibitor for the Treatment of PainACS Medicinal Chemistry Letters · 2026
15. Pharmacological inhibition of PMS2 induces MMR deficiency and response to immune checkpoint blockadeCancer Discovery · 2026
16. Drug-Induced Phospholipidosis as an Artifact in Antiviral Drug RepurposingACS Omega · 2026
17. Multimodal Preclinical Assessment of Glucocorticoid-Induced Disruption of Bone Remodeling in Sprague-Dawley RatsToxicological Sciences · 2026
18. Switchable and Selective Synthesis of Unsymmetrical N -Aryl Pyrazoles from 1,2,3-Thiadiazine S -OxidesJournal of the American Chemical Society · 2026
19. Evaluation of a research use only (RUO) TIMP-1 assay for use with the automated Alinity i platformBiochemistry and Biophysics Reports · 2026
20. Affinity selection mass spectrometry (AS-MS) as a tool to accelerate drug discovery effortsExpert Opinion on Drug Discovery · 2026