PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 1, 2026Journal of the American Chemical Society5 citationsOpen Access

Direct Access to Iron Carbenes from Aldehyde, Ketone, and Formamide Feedstocks

View Full Paper
PPP. Scott PedersenKBKatherine I BurtonSKSven H. Kaster

Key Points

  • The aim is to explore the conversion of carbonyl compounds to iron carbenes using aldehydes, ketones, and formamides.
  • Utilized mechanistic studies to analyze carbonyl activation.
  • Investigated concerted-asynchronous olefin addition pathways.
  • Demonstrated a direct carbonyl activation mechanism without free radical intermediates.
  • Established a general strategy for carbonyl-to-carbene conversion.

Abstract

-rich products. Mechanistic studies reveal direct carbonyl activation rather than free radical intermediacy, with a concerted-asynchronous olefin addition pathway. These findings establish a general strategy for carbonyl-to-carbene conversion, expanding the scope of base-metal catalysis and providing a blueprint for redefining carbonyl activation in synthetic chemistry.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Pedersen et al. (2026) studied this question.

synapsesocial.com/papers/69f44420967e944ac55672f9https://doi.org/10.1021/jacs.5c21614
Ask AI
Helpful
Bookmark
Share
View Full Paper