May 1, 2000Journal of Cardiovascular Pharmacology

ET-Receptor Subtypes: Roles in Regional Renal Vascular Actions of Exogenous and Endogenous Endothelins in Anesthetized Rabbits

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Population

Pentobarbitone-anesthetized rabbits

Comparison

Renal arterial infusion of ET-1, ET-agonist… vs Basal hemodynamics

Design

Preclinical

Authors

RERoger G. EvansGeneral Cardiology AMAnna C. MaddenPennington Biomedical Research Center ECEmma CotterillMonash University

Discussion

Member takes

Implication

Hypothesis-generating for ET(A)/ET(B2) cortical vasoconstriction in rabbits; should not yet inform human renal management or trials.

Structured PICO

Population

Pentobarbitone-anesthetized rabbits

Intervention

Renal arterial infusion of ET-1 (0.05-12.8 ng/kg/min), ET(B)-agonist [Ala1,3,11,15]-ET-1 (12.5-800 ng/kg/min), ET(A)-antagonist BQ610, and ET(B)-antagonist BQ788 (both 200 microg/kg plus 100 microg/kg/h, i.v.)

Comparator

Basal hemodynamics

Outcome

Total renal blood flow (RBF), cortical blood flow (CBF), medullary blood flow (MBF), and mean arterial pressure (MAP)surrogate

Endogenous and exogenous endothelins predominantly cause cortical vasoconstriction in the rabbit kidney, mediated by ET(A) and ET(B2)-like receptors, without affecting medullary blood flow.

Cite This Study

Evans et al. (2000) studied this question.

synapsesocial.com/papers/6a82f4bd28b8a62be998f80b https://doi.org/10.1097/00005344-200005000-00001

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ET-Receptor Subtypes: Roles in Regional Renal Vascular Actions of Exogenous and Endogenous Endothelins in Anesthetized Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ET-Receptor Subtypes: Roles in Regional Renal Vascular Actions of Exogenous and Endogenous Endothelins in Anesthetized Rabbits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider