Why the study?
What is the role of ETA and ETB receptor subtypes in the renal actions of low-dose exogenous endothelin in anesthetized dogs?
What is the role of ETA and ETB receptor subtypes in the renal actions of low-dose exogenous endothelin in anesthetized dogs?
In an in vivo dog model, the ETA receptor mediates endothelin-induced renal vasoconstriction, whereas the ETB receptor is largely responsible for the diuretic response.
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ETA/ETB receptor roles clarified in canine ET-1 responses; leaves open translation to human cardiorenal disease.
Clavell et al. (1995) studied this question.
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