Renal Actions of Endothelin-1 Under Endothelin Receptor Blockade by Be-18257b

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Why the study?

Does ET-A receptor blockade with BE-18257B alter the renal hemodynamic and tubular effects of ET-1 in anesthetized dogs?

Structured PICO

Does ET-A receptor blockade with BE-18257B alter the renal hemodynamic and tubular effects of ET-1 in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Intrarenal infusion of ET-1 at 2 ng/kg/min superimposed on ET-A receptor blocker BE-18257B at 100 ng/kg/min

Comparator

Intrarenal infusion of BE-18257B alone (100 ng/kg/min) or ET-1 alone (2 ng/kg/min)

Outcome

Renal hemodynamics (renal blood flow, GFR) and clearance measurements (urinary volume, sodium excretion, osmolality)surrogate

ET-A receptor blockade attenuates ET-1 induced renal vasoconstriction and unmasks ET-B receptor-mediated diuresis and natriuresis in dogs.

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ET-A blockade may protect renal hemodynamics in dogs; leaves open human translation and clinical trials.

Syed et al. (1998) studied this question.

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