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January 1, 1997Journal of the American Society of NephrologyOpen Access

Role of endothelin receptor subtypes in the systemic and renal responses to endothelin-1 in humans.

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Why the study?

Does endothelin-1 infusion alter systemic and renal hemodynamics compared to endothelin-3 in healthy volunteers?

Population

Healthy volunteers

Comparison

Systemic infusion of endothelin-1 vs Infusion of equimolar dosages of endothelin-3

Design

Other

Authors

KKKarin A. H. KaasjagerUniversity Medical Center UtrechtSSS. ShawUniversity of EdinburghHKH A KoomansUtrecht University

Discussion

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Implication

ETA selectivity likely mediates ET-1 renal effects in humans; leaves open therapeutic translation to disease states.

Structured PICO

Does endothelin-1 infusion alter systemic and renal hemodynamics compared to endothelin-3 in healthy volunteers?

P
Population
Healthy volunteers
I
Intervention
Systemic infusion of endothelin-1 (a nonselective receptor agonist)
C
Comparator
Infusion of equimolar dosages of endothelin-3 (an ETB-selective agonist)
O
Outcome
Blood pressure, renal hemodynamics (RPF, GFR), and electrolyte excretion (sodium excretion rate)surrogate

The systemic and renal vasoconstrictor effects of endothelin-1 in humans are predominantly mediated by ETA receptors, as ETB-selective stimulation with endothelin-3 produced no hemodynamic or renal effects.

Cite This Study

Kaasjager et al. (1997) studied this question.

synapsesocial.com/papers/6a830aa25b5082326951ad0ehttps://doi.org/10.1681/asn.v8132
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Also Consider

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  4. 4SEVERE ENDOTHELIAL INJURY IN A RENAL TRANSPLANT PATIENT RECEIVING CYCLOSPORINE1990 · 38 citations
  5. 5Endothelin: a potent renal and systemic vasoconstrictor peptide1989 · 232 citations