Why the study?
Does ETB receptor antagonism or Big ET-1 alter sodium excretion and intrarenal blood flow in anesthetized rats?
Population
Anesthetized rats on normal or high salt diet
Comparison
ETB antagonist A-192621 or Big ET-1 vs Control rats
Design
Preclinical
Follow-up
acute
Authors
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ETB antagonism impairs sodium excretion in rats; leaves open translation to human hypertension management.
Does ETB receptor antagonism or Big ET-1 alter sodium excretion and intrarenal blood flow in anesthetized rats?
Endothelin plays an important role in regulating sodium excretion through activation of ETB receptors, with medullary vasodilation produced by Big ET-1 being more prominent on a high salt diet.
Vassileva et al. (2003) studied this question.
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