What is the clinical evidence from this study?

Study design: Other. Population: Renal response to big ET-1. Intervention: ET(B)-selective antagonist A-192621 vs. Vehicle (0.9% NaCl). Primary outcome: Baseline mean arterial pressure (MAP) (p=< 0.05).

June 6, 2001Physiological Genomics

Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1

Q: What are the key findings of this study?

Pharmacological ET(B) blockade with A-192621 significantly increased baseline mean arterial pressure compared to vehicle (141 vs 102 mmHg, P<0.05) in rats.

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Key result

Pharmacological ET(B) blockade with A-192621 significantly increased baseline mean arterial pressure compared to vehicle (141 vs 102 mmHg, P<0.05) in rats.

Population

Inactin-anesthetized Sprague-Dawley rats and spotting lethal rats (genetic ET receptor deficiency model)

Comparison

ET-selective antagonist A-192621 or genetic ET… vs Vehicle for pharmacological blockade…

Design

Preclinical

Follow-up

60 minutes

Authors

DPDavid M. PollockPreventive Cardiology

Discussion

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Implication

ET(B) blockade raises arterial pressure in rats; hypothesis-generating for ET(B) modulation in hypertension.

Structured PICO

Population

Inactin-anesthetized Sprague-Dawley and spotting lethal rats used to study the role of ET(B) receptors in the renal response to big ET-1.

Intervention

ET(B)-selective antagonist A-192621 or genetic ET(B) receptor deficiency (sl/sl), followed by infusion of big ET-1 (10 pmol.kg(-1).min(-1)) for 60 min

Comparator

Vehicle (0.9% NaCl) for pharmacological blockade; heterozygous (sl/+) rats for genetic deficiency

Outcome

Renal hemodynamic response including mean arterial pressure (MAP), urine flow rate, glomerular filtration rate (GFR), and effective renal plasma flow (ERPF)surrogate

Main Result

Absolute Event Rate: 141% vs 102%

p-value: p=< 0.05

The ET(B) receptor plays an important role in limiting the renal hemodynamic response to big ET-1 and is required for its diuretic actions.

Cite This Study

David M. Pollock (2001) studied Renal response to big ET-1. ET(B)-selective antagonist A-192621 vs. Vehicle (0.9% NaCl) was evaluated on Baseline mean arterial pressure (MAP) (p=< 0.05). Pharmacological ET(B) blockade with A-192621 significantly increased baseline mean arterial pressure compared to vehicle (141 vs 102 mmHg, P<0.05) in rats.

synapsesocial.com/papers/6a830b7a332c0e417ef4665f https://doi.org/10.1152/physiolgenomics.2001.6.1.39

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Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Contrasting pharmacological ETB receptor blockade with genetic ETB deficiency in renal responses to big ET-1

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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