Key result
In anaesthetized rabbits, the ETA antagonist BQ610 increased total renal blood flow by 10%, while the ETB antagonist BQ788 reduced it by 16%.
In anaesthetized rabbits, endogenous endothelins act at ETA-receptors to reduce medullary and cortical blood flow, while ETB-receptors have little direct role in physiological control of renal hemodynamics.
No takes yet. Share an insight, caveat, or question.
Does not support clinical use of ETA antagonists for renal perfusion; leaves open differential ET receptor roles in human hemodynamics.
Evans et al. (2001) studied Anaesthetized rabbits (animal model). ETA- and ETB-receptor antagonists (BQ610 and BQ788) and ET-1 vs. Baseline/pretreatment was evaluated on Regional kidney blood flow and mean arterial pressure. In anaesthetized rabbits, the ETA antagonist BQ610 increased total renal blood flow by 10%, while the ETB antagonist BQ788 reduced it by 16%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: