April 22, 1991FEBS Letters

Presence of non‐selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation

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Population

Rat thoracic aorta and porcine thoracic aorta models

Design

Preclinical

Authors

Discussion

Should not inform clinical practice; hypothesis-generating for endothelial ETB receptor localization and vasodilation in mammals.

Population

Rat thoracic aorta and porcine thoracic aorta models

Intervention

[Glu9]-sarafotoxin S6b ([Glu9]SRTb), a ligand specific to the ETB receptor

Outcome

Presence of specific binding sites for 125I-[Glu9]SRTb and vasodilation responsesurrogate

This preclinical study demonstrates that ETB receptors are located on the vascular endothelium and mediate vasodilation.

Takayanagi et al. (1991) studied this question.

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