July 1, 1994Journal of Cardiovascular Pharmacology
Endothelin-1 Causes a Biphasic Response in Systemic Vasculature and Increases Myocardial Contractility in Conscious Rabbits
Key result
Intravenous endothelin-1 (0.2 nmol/kg) in conscious rabbits caused a brief initial vasodilation and increased myocardial contractility, followed by sustained vasoconstriction (P<0.001).
Population
Conscious rabbits (n=16)
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Warrants caution extrapolating rabbit ET-1 effects; leaves open human hemodynamic relevance.
Structured PICO
P
Population
16 conscious rabbits evaluated for the hemodynamic effects of intravenous endothelin-1.
I
Intervention
Intravenous (i.v.) bolus of endothelin-1 (ET-1, 0.2 nmol/kg)
O
Outcome
Arterial blood pressure (BP), heart rate (HR), myocardial contractility (LV dP/dt), cardiac output (CO), and total peripheral resistance (TPR)surrogate
Main Result
p-value: p=<0.001
In conscious rabbits, endothelin-1 induces a biphasic hemodynamic response characterized by initial vasodilation and increased contractility followed by sustained vasoconstriction.
Cite This Study
Roberts-Thomson et al. (1994) studied Conscious rabbits (animal model) (n=16). Endothelin-1 (ET-1) was evaluated on Arterial blood pressure, heart rate, myocardial contractility, cardiac output, and total peripheral resistance (p=<0.001). Intravenous endothelin-1 (0.2 nmol/kg) in conscious rabbits caused a brief initial vasodilation and increased myocardial contractility, followed by sustained vasoconstriction (P<0.001).