Key result
Intracoronary infusion of endothelin-1 did not induce any change in regional or global myocardial function in swine, unlike dobutamine which significantly increased segmental shortening (P<0.05).
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Questions direct myocardial effects of endothelin-1; leaves open its role in human coronary pathophysiology.
Absolute Event Rate: 30.8% vs 33.8%
Ricou et al. (1992) studied this question. Endothelin-1 (ET-1) vs. Dobutamine (10(-8) M) was evaluated on Segmental shortening. Intracoronary infusion of endothelin-1 did not induce any change in regional or global myocardial function in swine, unlike dobutamine which significantly increased segmental shortening (P<0.05).
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