Key result
Intracoronary ET-1 elicited positive inotropic effects (end-systolic elastance increased from 0.94 to 1.48) and negative lusitropic effects (tau increased from 41.5 to 58.1) in a pig model.
Why the study?
Does endothelin receptor agonism alter myocardial contractility and relaxation in an in vivo pig model?
Population
Anesthetized pigs
Design
Preclinical
Authors
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May guide ET-targeted research in myocardial function; leaves open translation from porcine model to clinical practice.
Does endothelin receptor agonism alter myocardial contractility and relaxation in an in vivo pig model?
Endothelin-1 exerts positive inotropic effects via ET(A) receptors and negative lusitropic effects via ET(B) receptors in an in vivo pig model.
Konrad et al. (2005) studied this question. Intracoronary infusions of ET-1 and sarafotoxin 6c was evaluated on Myocardial contractile status and left ventricular isovolumic relaxation. Intracoronary ET-1 elicited positive inotropic effects (end-systolic elastance increased from 0.94 to 1.48) and negative lusitropic effects (tau increased from 41.5 to 58.1) in a pig model.
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