January 1, 1997British Journal of PharmacologyOpen Access

Inhibitory effects of TAK‐044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists

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Population

Canine arteries (coronary, femoral, renal, mesenteric, basilar) and porcine coronary arteries

Comparison

TAK-044 (10 nM - 100 nM) vs Selective ETA receptor antagonist and ETB…

Design

Preclinical

Authors

YAYumiko Awane‐Igata SIShota IkedaSaga University TWToshifumi WatanabeJichi Medical University

Discussion

Member takes

Implication

Supports dual ET receptor blockade in coronary models; leaves open translation to human disease.

Structured PICO

Population

Canine arteries (coronary, femoral, renal, mesenteric, basilar) and porcine coronary arteries

Intervention

TAK-044 (10 nM - 100 nM)

Comparator

Selective ETA receptor antagonist (BQ-123) and ETB receptor antagonist (BQ-788), or control

Outcome

Inhibition of endothelin-induced vasoconstrictionsurrogate

TAK-044 is a non-selective endothelin receptor antagonist that effectively inhibits both ETA and ETB receptor-mediated vasoconstriction in coronary arteries.

Cite This Study

Awane‐Igata et al. (1997) studied this question.

synapsesocial.com/papers/6a8b1f9e0269824ff833716f https://doi.org/10.1038/sj.bjp.0700925

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Inhibitory effects of TAK‐044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibitory effects of TAK‐044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider