January 1, 1995British Journal of PharmacologyOpen Access

Endothelin‐1 and endothelin‐3 regulate differently vasoconstrictor responses of smooth muscle of the porcine coronary artery

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Population

Medial strips of the porcine coronary artery

Design

Preclinical

Authors

MUMasuko Ushio‐FukaiVascular / Pulmonary Vascular JNJunji NishimuraFukuoka Institute of Technology SKSei KobayashiShowa University

Discussion

Member takes

Implication

Differential ET calcium signaling in porcine arteries merits human vessel studies; leaves open ETA blockade effects by ligand in coronary disease.

Structured PICO

Population

Medial strips of the porcine coronary artery

Intervention

Endothelin-1 (ET-1) (10(-10)-10(-7) M) and Endothelin-3 (ET-3) (10(-8)-10(-5) M)

Outcome

Cytosolic Ca2+ concentrations ([Ca2+]i) and tensionsurrogate

ET-1 and ET-3 induce vasoconstriction in porcine coronary arteries via distinct intracellular calcium signaling mechanisms despite both acting through ETA receptors.

Cite This Study

Ushio‐Fukai et al. (1995) studied this question.

synapsesocial.com/papers/6a870ee2b712452940cbb557 https://doi.org/10.1111/j.1476-5381.1995.tb14922.x

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Implication

Differential ET calcium signaling in porcine arteries merits human vessel studies; leaves open ETA blockade effects by ligand in coronary disease.

Endothelin‐1 and endothelin‐3 regulate differently vasoconstrictor responses of smooth muscle of the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin‐1 and endothelin‐3 regulate differently vasoconstrictor responses of smooth muscle of the porcine coronary artery

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider