Population
Vascular rings of left anterior descending artery or left circumflex artery from 7 pigs
Comparison
Exposure to ET-1 and ET-3 in the presence or… vs Vascular rings without endothelium, or without…
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for ET receptor subtype roles in coronary vasomotion.
In porcine coronary arteries, ETB receptors on the endothelium mediate transient vasodilation via nitric oxide, whereas ETA and ETB receptors on smooth muscle cells mediate vasoconstriction.
Hong et al. (1998) studied this question.
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