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February 1, 1993Journal of Cardiovascular Pharmacology

Acetylcholine causes direct smooth muscle contraction minimized by NO; serotonin relaxation is NO-dependent; substance P relaxation involves both L-NA-sensitive and L-NA-resistant NO pathways.

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Population

Isolated porcine coronary arteries

Comparison

Vasoactive agents with or without… vs Endothelium denudation vs intact; presence vs…

Design

Preclinical

Authors

TMTetsuya MatsumotoMKMasahiko KinoshitaNTNoboru Toda

Discussion

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Overview

Porcine findings require human validation before any clinical inference; leaves open translation of distinct NO pathways to coronary vasoreactivity.

Structured PICO

P
Population
Isolated porcine coronary arteries
I
Intervention
Vasoactive agents (acetylcholine, serotonin, substance P) with or without NG-nitro-L-arginine (L-NA)
C
Comparator
Endothelium denudation vs intact; presence vs absence of L-NA
O
Outcome
Vascular contraction and relaxation responsessurrogate

This preclinical study elucidates the distinct endothelial NO-dependent and independent pathways mediating the vasoactive effects of acetylcholine, serotonin, and substance P in porcine coronary arteries.

Cite This Study

Matsumoto et al. (1993) studied this question.

synapsesocial.com/papers/6a8969d9186271ac99333d27https://doi.org/10.1097/00005344-199302000-00007
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