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May 1, 1989Circulation ResearchOpen Access

Endothelium-dependent relaxations to aggregating platelets and related vasoactive substances were severely impaired in atherosclerotic LAD and moderately impaired in hypercholesterolemic LCX.

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Why the study?

Does balloon endothelial denudation combined with high-cholesterol feeding impair endothelium-dependent relaxation in porcine coronary arteries?

Population

Male Yorkshire pigs

Comparison

Balloon endothelial denudation of the left… vs Left circumflex coronary artery exposed to…

Design

Preclinical

Follow-up

10 weeks

Authors

HSHiroaki ShimokawaPVPaul M. Vanhoutte

Discussion

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Overview

Impaired endothelial function in atherosclerotic porcine coronaries; hypothesis-generating for mechanisms in human atherosclerosis.

Structured PICO

Does balloon endothelial denudation combined with high-cholesterol feeding impair endothelium-dependent relaxation in porcine coronary arteries?

P
Population
Male Yorkshire pigs
I
Intervention
Balloon endothelial denudation of the left anterior descending coronary artery (LAD) and 2% high-cholesterol feeding for 10 weeks
C
Comparator
Left circumflex coronary artery (LCX) exposed to high-cholesterol feeding without balloon denudation
O
Outcome
Endothelium-dependent relaxations to aggregating platelets and related vasoactive substances in vitrosurrogate

Endothelium-dependent relaxations to aggregating platelets and vasoactive substances are severely impaired in atherosclerosis due to depressed release of endothelium-derived relaxing factors and concomitant release of cyclooxygenase vasoconstrictors.

Cite This Study

Shimokawa et al. (1989) studied this question.

synapsesocial.com/papers/6a6fb74031a3df8243280a02https://doi.org/10.1161/01.res.64.5.900
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.1988 · 264 citations
  2. 2Enhanced Endothelin-B-Receptor–Mediated Vasoconstriction of Small Porcine Coronary Arteries in Diet-Induced Hypercholesterolemia1997 · 45 citations
  3. 3Enhanced Endothelin-Mediated Coronary Vasoconstriction and Attenuated Basal Nitric Oxide Activity in Experimental Hypercholesterolemia1997 · 102 citations
  4. 4Mechanisms of Endothelium-Dependent Responses to Vasoactive Agents in Isolated Porcine Coronary Arteries1993 · 23 citations
  5. 5Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.1992 · 234 citations