Key result
Administration of L-arginine for 40 minutes restored blunted endothelium-dependent vasodilation to pharmacological stimulation and flow in coronary arterioles from atherosclerotic pigs.
Why the study?
Does L-arginine restore endothelium-dependent vasoactive responses in coronary arterioles from atherosclerotic pigs?
Population
Isolated, cannulated coronary arterioles (30-70 microns in diameter) from normal and atherosclerotic pigs
Comparison
L-arginine administration for 40 minutes vs Control conditions and arterioles from normal pigs
Design
Preclinical
Authors
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May support L-arginine testing in human coronary microvascular dysfunction; leaves open clinical translation from porcine atherosclerosis.
Does L-arginine restore endothelium-dependent vasoactive responses in coronary arterioles from atherosclerotic pigs?
L-arginine restores impaired endothelium-dependent vasodilation in the coronary microcirculation downstream of atherosclerotic lesions in a porcine model.
Kuo et al. (1992) studied Atherosclerosis. L-arginine vs. Control conditions was evaluated on Endothelium-dependent vasodilation to pharmacological stimulation and flow. Administration of L-arginine for 40 minutes restored blunted endothelium-dependent vasodilation to pharmacological stimulation and flow in coronary arterioles from atherosclerotic pigs.