Population
Pigs with hypertension induced by aortic coarctation and normotensive pigs.
Comparison
Inhibition of arginase activity by… vs Normotensive vessels and untreated hypertensive…
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
May support arginase inhibition for hypertension-related endothelial dysfunction; leaves open clinical translation from animal models.
Upregulation of vascular arginase in hypertension limits L-arginine availability for NO production, contributing to decreased NO-mediated vasodilation in coronary arterioles.
Zhang et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: