Population
Porcine heart model
Comparison
Local ischemia-reperfusion with or without… vs Non-ischemic regions (normal vessels)
Design
Preclinical
Authors
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Arteriolar NO protection by arginase blockade remains unproven in patients; leaves open whether this mechanism improves outcomes after I/R.
Ischemia-reperfusion impairs NO-mediated coronary arteriolar dilation partly through up-regulation of arginase, which limits L-arginine availability for NO synthase.
Hein et al. (2003) studied this question.
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