Why the study?
Does l-arginine prevent ischemia-reperfusion-induced endothelial dysfunction in healthy male subjects?
Population
16 healthy male subjects
Comparison
15-min intrabrachial artery infusion of… vs Vehicle starting at 15 min of ischemia
Design
Other
Follow-up
60-min reperfusion
Authors
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Does not support clinical use; leaves open translation of l-arginine benefit to human ischemia-reperfusion.
Does l-arginine prevent ischemia-reperfusion-induced endothelial dysfunction in healthy male subjects?
Intra-arterial infusion of the nitric oxide substrate l-arginine significantly attenuates ischemia-reperfusion-induced endothelial dysfunction in humans in vivo.
Pernow et al. (2003) studied this question.
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