Key result
L-arginine limits ischemia/reperfusion injury and improves hemodynamics, though excessive dosing poses potential hazards.
Why the study?
The effects of L-arginine administration on ischemia/reperfusion injury and its potential hazards in conditions with stimulated inducible NOS were not fully clarified.
Does L-arginine administration reduce ischemia/reperfusion injury in experimental models?
Does L-arginine administration reduce ischemia/reperfusion injury in experimental models?
L-arginine administration shows potential in reducing ischemia/reperfusion injury in experimental models, but high doses may be harmful when inducible NOS is stimulated.
L-arginine may protect against experimental ischemia/reperfusion injury; leaves open clinical translation and safety when inducible NOS is stimulated.
Several experimental studies have revealed that the administration of L-arginine can reduce ischemia/reperfusion injury to skeletal muscle, kidney, liver, heart and brain. Moreover, the administration of L-arginine can cause protective hemodynamic alterations. However, in situations with a stimulated inducible NOS, the administration of large amounts of L-arginine may be hazardous for the patients.
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Erich Roth (1998) conducted a review in Ischemia/reperfusion injury. L-arginine was evaluated on Ischemia/reperfusion injury. Administration of L-arginine can reduce ischemia/reperfusion injury and cause protective hemodynamic alterations, but large amounts may be hazardous with stimulated inducible NOS.
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