August 1, 1995Cardiovascular Research

L-Arginine reverses low coronary reflow and enhances postischaemic recovery of cardiac mechanical function

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Why the study?

Does L-arginine improve coronary flow and mechanical function in isolated rat hearts following cardioplegic arrest?

Population

Isolated rat hearts subjected to cardioplegic arrest for 4 h at 4 degrees C (n=31)

Comparison

L-arginine administered during reperfusion vs Krebs buffer, L-lysine, and L-NMMA

Design

Preclinical

Authors

MAMohamed AmraniMohammed V University ACAdrian H. ChesterInterventional / Structural Cardiology JJJ JayakumarBrooklyn Hospital Center

Discussion

Member takes

Implication

L-arginine augments recovery in this rat model; hypothesis-generating for adjunctive use in human cardioplegia, trials needed.

Structured PICO

Does L-arginine improve coronary flow and mechanical function in isolated rat hearts following cardioplegic arrest?

Population

Isolated rat hearts subjected to cardioplegic arrest for 4 h at 4 degrees C (n=31)

Intervention

L-arginine (1, 2, and 4 mmol/l) administered during reperfusion

Comparator

Krebs buffer (control), L-lysine (1 mmol/l), and L-NMMA (0.5 mmol/l)

Outcome

Coronary flow and mechanical function (cardiac output) during reperfusionsurrogate

Exogenous administration of L-arginine improves low coronary reflow and postischaemic mechanical function in an isolated rat heart model of cardioplegic arrest.

Cite This Study

Amrani et al. (1995) studied this question.

synapsesocial.com/papers/6a868bc38f44213313b2e856 https://doi.org/10.1016/s0008-6363(95)00021-6

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L-Arginine reverses low coronary reflow and enhances postischaemic recovery of cardiac mechanical function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

L-Arginine reverses low coronary reflow and enhances postischaemic recovery of cardiac mechanical function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider