Why the study?
Does intracoronary L-arginine during reperfusion reduce infarct size in a canine model of ischemia-reperfusion?
Population
Open-chest, anesthetized dogs undergoing 60 min of left anterior descending coronary arterial occlusion…
Comparison
Intracoronary 10 mM L-arginine in the LAD during… vs Intracoronary 10 mM D-arginine or saline vehicle
Design
Preclinical
Follow-up
270 minutes of reperfusion
Authors
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Preclinical L-arginine data in canine reperfusion; leaves open human translation and clinical testing.
Does intracoronary L-arginine during reperfusion reduce infarct size in a canine model of ischemia-reperfusion?
Intracoronary L-arginine during early reperfusion reduces infarct size and preserves endothelial function in a canine model of ischemia-reperfusion.
Nakanishi et al. (1992) studied this question.
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