Key result
L-Arginine treatment decreased infarct size by 31% (101 vs 147 mm3, P<0.05) in spontaneously hypertensive rats subjected to distal middle cerebral arterial and ipsilateral common carotid occlusion.
Why the study?
Does L-arginine reduce infarct size in spontaneously hypertensive rats subjected to focal cerebral ischemia?
Does L-arginine reduce infarct size in spontaneously hypertensive rats subjected to focal cerebral ischemia?
Effect estimate: decreased by 31%
Absolute Event Rate: 101% vs 147%
p-value: p=< 0.05
L-arginine administration significantly reduces infarct size in a rat model of focal cerebral ischemia, suggesting a potential neuroprotective role via nitric oxide synthesis.
No takes yet. Share an insight, caveat, or question.
Supports nitric oxide precursor investigation in hypertensive stroke models; should not yet alter clinical management.
Morikawa et al. (1992) studied Focal cerebral ischemia. L-arginine vs. Saline was evaluated on Volume of infarction (infarct size) (decreased by 31%, p=< 0.05). L-Arginine treatment decreased infarct size by 31% (101 vs 147 mm3, P<0.05) in spontaneously hypertensive rats subjected to distal middle cerebral arterial and ipsilateral common carotid occlusion.
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