What is the clinical evidence from this study?

Study design: RCT. Population: acute myocardial infarction (n=30). Intervention: L-Arginine vs. sham group and normal saline group. Primary outcome: cardiac function (LVEF, LVFS, LVEDD, LVESD), scar area, and plasma BNP (p=< 0.01).

What question did this study set out to answer?

To investigate whether oral L-arginine supplementation improves ventricular remodeling after acute myocardial infarction by regulating angiogenesis, arteriogenesis, and collagen synthesis.

January 1, 2019American Journal of Clinical and Experimental MedicineOpen Access

Oral Supplementation of L-Arginine Improves Ventricular Remodeling by Regulating Angiogenesis and Collagen Synthesis in Myocardial Infarction Rats

Q: What are the key findings of this study?

L-Arginine supplementation improved cardiac function and reduced scar percentage and plasma BNP levels (P<0.01) in rats with acute myocardial infarction.

Q: What question did this study set out to answer?

To investigate whether oral L-arginine supplementation improves ventricular remodeling after acute myocardial infarction by regulating angiogenesis, arteriogenesis, and collagen synthesis.

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Key result

L-Arginine supplementation improved cardiac function and reduced scar percentage and plasma BNP levels (P<0.01) in rats with acute myocardial infarction.

Why the study?

To investigate the effect of L-arginine therapy on angiogenesis and collagen synthesis in the peri-infarct area in acute myocardial infarction rats.

Does oral supplementation of L-Arginine improve ventricular remodeling and cardiac function in a rat model of acute myocardial infarction?

Comparison

L-Arginine vs sham vs normal saline

Design

Randomized preclinical animal study

Authors

YLYonghua LiuChinese Academy of Medical Sciences & Peking Union Medical College ZZZhijuan ZhouFifth Affiliated Hospital of Sun Yat-sen University ZZZhiling ZhuZhejiang University of Technology

Discussion

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Implication

Hypothesis-generating in rat MI model; leaves open translation to human ventricular remodeling.

Key Points

To investigate whether oral L-arginine supplementation improves ventricular remodeling after acute myocardial infarction by regulating angiogenesis, arteriogenesis, and collagen synthesis.
Acute myocardial infarction was induced in male Sprague-Dawley rats (N=30) via surgical ligation of the left anterior descending coronary artery.
Rats were randomly assigned to an L-arginine group, a sham group, or a normal saline control group and followed for four weeks.
Cardiac structure and function were evaluated using echocardiography, Masson staining, ELISA, immunohistochemistry, Western blot, and qPCR.
Four weeks post-ligation, LVEF and LVFS were significantly higher, while LVEDD and LVESD were significantly decreased in the L-arginine group compared to controls (P < 0.01).
Average myocardial scar percentage and plasma BNP concentrations were significantly lower in the L-arginine group than in controls (P < 0.01).
CD31-positive and α-SMA-positive microvessels in the peri-infarct zone were significantly increased, while collagen I protein and mRNA expression were significantly reduced with L-arginine treatment (P < 0.01).

Study Design

Type

RCT (n=30)

Randomization

randomly divided

Structured PICO

Does oral supplementation of L-Arginine improve ventricular remodeling and cardiac function in a rat model of acute myocardial infarction?

Population

30 male Sprague-Dawley rats with acute myocardial infarction induced by LAD ligation, followed for 4 weeks.

Intervention

Oral supplementation of L-Arginine.

Comparator

Normal saline and sham operation.

Outcome

Cardiac function, scar area, plasma concentration of BNP, angiogenesis and arteriogenesis, myocardial collagen I and eNOS protein, and mRNA expression of collagen I at 4 weeks.surrogate

Main Result

p-value: p=< 0.01

Oral L-Arginine supplementation improves cardiac function and reduces infarct size in a rat model of myocardial infarction by promoting angiogenesis and regulating collagen synthesis.

Cite This Study

Liu et al. (2019) conducted an RCT in acute myocardial infarction (n=30). L-Arginine vs. sham group and normal saline group was evaluated on cardiac function (LVEF, LVFS, LVEDD, LVESD), scar area, and plasma BNP (p=< 0.01). L-Arginine supplementation improved cardiac function and reduced scar percentage and plasma BNP levels (P<0.01) in rats with acute myocardial infarction.

synapsesocial.com/papers/6a95ce57db04510482c5d6e1 https://doi.org/10.11648/j.ajcem.20190702.12

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Oral Supplementation of L-Arginine Improves Ventricular Remodeling by Regulating Angiogenesis and Collagen Synthesis in Myocardial Infarction Rats

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Oral Supplementation of L-Arginine Improves Ventricular Remodeling by Regulating Angiogenesis and Collagen Synthesis in Myocardial Infarction Rats

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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