Why the study?
Does L-arginine improve regional cerebral blood flow in spontaneously hypertensive rats with focal cerebral ischaemia?
Population
Spontaneously hypertensive rats with unilateral common carotid/middle cerebral artery occlusion
Comparison
L-Arginine administered 5 min after occlusion vs D-arginine (300 mg kg-1) and baseline
Design
Preclinical
Authors
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L-arginine may enhance rCBF in this rat model; leaves open translation to human stroke.
Does L-arginine improve regional cerebral blood flow in spontaneously hypertensive rats with focal cerebral ischaemia?
L-arginine increases regional cerebral blood flow during focal cerebral ischaemia in rats via nitric oxide-dependent mechanisms.
Morikawa et al. (1992) studied this question.
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