Why the study?
Does intrapericardial L-arginine reduce ventricular arrhythmias during sympathetic stimulation in dogs with acute coronary occlusion?
Population
43 autonomically denervated dogs with acute coronary occlusion
Comparison
Intrapericardial delivery of L-arginine for 30… vs Control and/or co-administration of…
Design
Preclinical
Follow-up
30 minutes
Authors
Loading...
May attenuate sympathetic arrhythmias in canine ischemia; hypothesis-generating and leaves open human translation.
Does intrapericardial L-arginine reduce ventricular arrhythmias during sympathetic stimulation in dogs with acute coronary occlusion?
Intrapericardial L-arginine reduces the severity of ischemic ventricular arrhythmias during sympathetic stimulation in a canine model, likely by reducing norepinephrine release.
Lu et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: