Electrophysiology
Ventricular arrhythmias
VT, VF, and sudden cardiac death prevention
Emerging pathwayAlso known as: VT, ventricular tachycardia, VF, ventricular fibrillation
4,669
Clinical questions
314
Evidence-backed
100
Claims analyzed
Electrophysiology
VT, VF, and sudden cardiac death prevention
Synthesized from 314 evidence-backed clinical questions linked to this topic — 9 supporting the intervention, 19 against the intervention, 7 still contested.
Does women vs placebo improve outcomes in Paroxysmal supraventricular tachycardia?
Low Certainty− Favors harmwomen vs placebo
2 studies (146,070 patients) provide low-certainty evidence against benefit of women for the outcome in Paroxysmal supraventricular tachycardia.
Does dexmedetomidine vs placebo improve outcomes in Supraventricular tachycardia?
Low Certainty− Favors harmdexmedetomidine vs placebo · Sustained Ventricular Tachycardia
2 studies (14,552 patients) provide low-certainty evidence against benefit of dexmedetomidine for Sustained Ventricular Tachycardia in Supraventricular tachycardia.
Does amiodarone vs placebo improve outcomes in Tachycardia, Ventricular?
Low Certainty+ Favors benefitamiodarone vs placebo
15 studies (5,632 patients) provide low-certainty evidence for benefit of amiodarone for the outcome in Tachycardia, Ventricular.
Does antiarrhythmic drugs vs placebo improve outcomes in Tachycardia, Ventricular?
Low Certainty+ Favors benefitantiarrhythmic drugs vs placebo
4 studies (4,557 patients) provide low-certainty evidence for benefit of antiarrhythmic drugs for the outcome in Tachycardia, Ventricular.
Does Propranolol and flecainide vs placebo improve outcomes in 14-year-old male who suffered out-of-hospital cardiac arrest (ventricular fibrillation) with a rare RYR2 variant (c.12370A>G)?
Low Certainty− Favors harmPropranolol and flecainide vs placebo
13 studies (2,017 patients) provide low-certainty evidence against benefit of Propranolol and flecainide for the outcome in 14-year-old male who suffered out-of-hospital cardiac arrest (ventricular fibrillation) with a rare RYR2 variant (c.12370A>G).
Does propofol vs fentanyl improve outcomes in Tachycardia, Ventricular?
Low Certainty− Favors harmpropofol vs fentanyl
6 studies (776 patients) provide low-certainty evidence against benefit of propofol for the outcome in Tachycardia, Ventricular.
Does Primary-prevention implantable cardioverter-defibrillator (ICD) implantation, followed by oral anticoagulation and flecainide therapy vs placebo improve outcomes in 50-year-old woman with mitral valve prolapse, frequent premature ventricular complexes, polymorphic non-sustained ventricular tachycardia, prior ischemic stroke, and myocardial infarction with non-obstructive coronary arteries (MINOCA)?
Insufficient~ Mixed resultsPrimary-prevention implantable cardioverter-defibrillator (ICD) implantation, followed by oral anticoagulation and flecainide therapy vs placebo
3 studies (0 patients) provide insufficient evidence with mixed findings regarding Primary-prevention implantable cardioverter-defibrillator (ICD) implantation, followed by oral anticoagulation and flecainide therapy for the outcome in 50-year-old woman with mitral valve prolapse, frequent premature ventricular complexes, polymorphic non-sustained ventricular tachycardia, prior ischemic stroke, and myocardial infarction with non-obstructive coronary arteries (MINOCA).
Does catheter ablation vs placebo improve outcomes in Tachycardia, Ventricular?
Emerging evidence with 100 primary claims
Specific, answerable questions in this area — each with its own synthesized evidence and consensus. Open one to see the forest plot, source trials, and how the consensus has changed over time.
Does dexmedetomidine vs placebo improve outcomes in Supraventricular tachycardia?
Low Certainty− Favors harmdexmedetomidine vs placebo · Sustained Ventricular Tachycardia
Does beta-blockers vs flecainide improve outcomes in Polymorphic catecholergic ventricular tachycardia?
Low Certainty− Favors harmbeta-blockers vs flecainide · Sustained Ventricular Tachycardia
New-Onset Sustained Ventricular Tachycardia After Cardiac Surgery
Circulation — Steinberg J — Feb 1999
Improving the detection of ventricular tachycardia: a smarter implantable loop recorder
EP Europace — Hemel N — Mar 2013
Pacemaker‐Mediated Polymorphic Ventricular Tachycardia
Pacing and Clinical Electrophysiology — Goldman D — Oct 1998
Reduction of ICD Shock Burden by Eliminating Back‐Up Pacing Induced Ventricular Tachyarrhythmias
Journal of Cardiovascular Electrophysiology — Theis C — Mar 2014
Procainamide pharmacokinetics during extracorporeal membrane oxygenation
Perfusion — Vollmer N — Oct 2021
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Ventricular arrhythmias (also known as VT, ventricular tachycardia, VF). VT, VF, and sudden cardiac death prevention
Synapse tracks 5 specific clinical questions in Ventricular arrhythmias, each synthesized independently from its own trial evidence. They include: "Does dexmedetomidine vs placebo improve outcomes in Supraventricular tachycardia?"; "Does beta-blockers vs flecainide improve outcomes in Polymorphic catecholergic ventricular tachycardia?"; "Does beta-blockers vs flecainide improve Sustained Ventricular Tachycardia in Polymorphic catecholergic ventricular tachycardia?"; "Does amiodarone vs placebo improve Sustained Ventricular Tachycardia in Wolff-Parkinson-White Syndrome?"; "Does adenosine vs placebo improve Sustained Ventricular Tachycardia in Paroxysmal supraventricular tachycardia?".
As of 2026-08-14, the scientific consensus on Ventricular arrhythmias is emerging. Emerging evidence with 100 primary claims Based on 100 analyzed claims across Synapse's enriched corpus, the evidence shows.
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/ventricular-arrhythmias.
Deterministic synthesis from Synapse's enriched corpus — 131 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Ventricular arrhythmias paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
Search Ventricular arrhythmias papersPowered by Synapse — AI-enriched analysis of 600,000+ peer-reviewed papers
catheter ablation vs placebo
3 studies (60,042 patients) provide insufficient evidence with mixed findings regarding catheter ablation for the outcome in Tachycardia, Ventricular.
Psychological vulnerability, ventricular tachyarrhythmias and mortality in implantable cardioverter defibrillator patients: is there a link?
Expert Review of Medical Devices — Pedersen S — Jul 2012