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January 1, 2000Archives of Physiology and Biochemistry

L-arginine failed to modify hypertension development but significantly diminished tension development to all agonists (p<0.05) and improved PGI2 synthesis under PDBu stimulation in hypertensive rats.

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Why the study?

Does L-arginine supplementation improve blood pressure and vascular function in two kidney-two clip hypertensive rats?

Population

Two kidney-two clip (2K-2C) hypertensive rats (n=15) and sham-operated rats (n=21)

Comparison

L-arginine in drinking water for 3 weeks vs No L-arginine supplementation (control groups)

Design

Preclinical

Follow-up

3 weeks

Authors

IRIvano RivaMRMaría Inés RosónGVG W Vega

Discussion

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Member takes

Overview

Does not support L-arginine for blood pressure reduction in this model; leaves open vascular effects for further study.

Structured PICO

Does L-arginine supplementation improve blood pressure and vascular function in two kidney-two clip hypertensive rats?

P
Population
Two kidney-two clip (2K-2C) hypertensive rats (n=15) and sham-operated rats (n=21)
I
Intervention
L-arginine (1.25 g/L) in drinking water for 3 weeks
C
Comparator
No L-arginine supplementation (control groups)
O
Outcome
Blood pressure, plasma nitrite/nitrate concentrations, and aortic contractile responsesurrogate

In a rat model of renovascular hypertension, oral L-arginine supplementation did not lower blood pressure but reduced vascular contractility and improved prostacyclin synthesis.

Cite This Study

Riva et al. (2000) studied this question.

synapsesocial.com/papers/6a71368bf44fa9f079defd93https://doi.org/10.1076/apab.108.5.415.4298
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Nitric Oxide in the Evolution of Renal Ischemia in Two-Kidney, One-Clip Renovascular Hypertension.1998 · 16 citations
  2. 2L‐NITROARGININE INCREASES BLOOD PRESSURE IN THE RAT1991 · 23 citations
  3. 3Chronic <scp>l</scp> -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats1996 · 117 citations
  4. 4Exogenous <scp>L</scp>‐arginine attenuates the effects of angiotensin <scp>II</scp> on renal hemodynamics and the pressure natriuresis–diuresis relationship2014 · 6 citations
  5. 5Role of L-arginine-nitric oxide pathway in hypertension1993 · 91 citations