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June 1, 1991Clinical and Experimental Pharmacology and Physiology

L‐nitroarginine Increases Blood Pressure in the Rat

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Authors

YKYuta KobayashiKIKatsumi IkedaKSKazumasa Shinozuka

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Overview

NO synthase inhibition raises BP and impairs endothelial relaxation in rats; leaves open relevance to human hypertension mechanisms or therapy.

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Cite This Study

Kobayashi et al. (1991) studied this question.

synapsesocial.com/papers/6a9808e2883af1d6c8a69050https://doi.org/10.1111/j.1440-1681.1991.tb01470.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMPARISON OF VASOPRESSOR EFFECTS OF NITRO ARGININE IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS AND WISTAR‐KYOTO RATS1991 · 10 citations
  2. 2Quinapril Prevents Hypertension and Enhanced Vascular Reactivity in Nitroarginine-treated Rats1997 · 3 citations
  3. 3Effect of Oral L-Arginine Administration for Three Weeks in Two Kidney-two Clip Hypertensive Rats2000 · 12 citations
  4. 4NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?1989 · 432 citations
  5. 5Mechanism of Hypertension Induced by Chronic Inhibition of Nitric Oxide in Rats.1995 · 22 citations