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January 1, 1997Blood PressureOpen Access

Quinapril Prevents Hypertension and Enhanced Vascular Reactivity in Nitroarginine-treated Rats

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Why the study?

Does quinapril prevent hypertension and enhanced vascular reactivity in L-NNA-treated rats?

Population

Adult Sprague-Dawley rats

Comparison

N omega Nitro-L-arginine combined with quinapril… vs L-NNA alone

Design

Preclinical

Follow-up

2 weeks

Authors

JCJohn R. CharpieUniversity of MichiganPCPeggy M. CharpieCGChetan Goud

Discussion

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Implication

Hypothesis-generating in rat NOS-inhibition model; leaves open whether quinapril effects translate to human hypertension.

Structured PICO

Does quinapril prevent hypertension and enhanced vascular reactivity in L-NNA-treated rats?

P
Population
Adult Sprague-Dawley rats
I
Intervention
N omega Nitro-L-arginine (L-NNA) combined with quinapril for 2 weeks
C
Comparator
L-NNA alone
O
Outcome
Systolic blood pressure and vascular reactivity (contractile force and vasodilation in thoracic aorta)surrogate

In a rat model of NOS inhibition, quinapril prevents hypertension and abnormal vascular reactivity, highlighting the role of the renin-angiotensin system in this hypertensive response.

Cite This Study

Charpie et al. (1997) studied this question.

synapsesocial.com/papers/6a924ccb8a638c790c5efe5dhttps://doi.org/10.3109/08037059709061810

Topics

Hypertension management
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