What does this research mean for the field?

Inhibition of angiotensin-converting enzyme with quinapril reverses hypertension, prevents end-stage vascular damage, and improves survival in rats with chronic nitric oxide synthase blockade, independent of arterial wall cyclic GMP levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1996Journal of Cardiovascular Pharmacology

Improved Survival in Rats Administered NG-Nitro L-Arginine Methyl Ester Due to Converting Enzyme Inhibition

View Full Paper

Ask AI

Bookmark

Why the study?

Does quinapril improve survival and prevent tissue damage in rats administered L-NAME?

Population

Rats administered NG-nitro L-arginine methyl ester to induce chronic nitric oxide synthase blockade

Comparison

Quinapril starting 1 month after L-NAME… vs L-NAME alone (50 mg/kg) and untreated controls

Design

Preclinical

Follow-up

Up to 4 months

Authors

JMJean‐Baptiste MichelVascular / Pulmonary Vascular YXYichun XuShanghai Jiao Tong University SBStéphane BlotInserm

Discussion

Member takes

Implication

Hypothesis-generating in L-NAME rat model; leaves open clinical translation of quinapril benefits.

Structured PICO

Does quinapril improve survival and prevent tissue damage in rats administered L-NAME?

Population

Rats administered NG-nitro L-arginine methyl ester (L-NAME) (50 mg/kg) to induce chronic nitric oxide synthase blockade

Intervention

Quinapril (10 mg/kg) starting 1 month after L-NAME administration

Comparator

L-NAME alone (50 mg/kg) and untreated controls

Outcome

Survival rate, blood pressure, renal function, and tissue morphology (renal and cervical medulla)hard clinical

ACE inhibition with quinapril reverses hypertension and prevents end-stage vascular damage and mortality induced by chronic nitric oxide synthase blockade in rats.

Cite This Study

Michel et al. (1996) studied this question.

synapsesocial.com/papers/6a1a1cf6443d3ecd7cdf5cf7 https://doi.org/10.1097/00005344-199607000-00021

View Full Paper

Ask AI

Bookmark

July 1, 1996Journal of Cardiovascular Pharmacology

Improved Survival in Rats Administered NG-Nitro L-Arginine Methyl Ester Due to Converting Enzyme Inhibition

View Full Paper

Ask AI

Bookmark

Why the study?

Does quinapril improve survival and prevent tissue damage in rats administered L-NAME?

Population

Rats administered NG-nitro L-arginine methyl ester to induce chronic nitric oxide synthase blockade

Comparison

Quinapril starting 1 month after L-NAME… vs L-NAME alone (50 mg/kg) and untreated controls

Design

Preclinical

Follow-up

Up to 4 months

Authors

JMJean‐Baptiste MichelVascular / Pulmonary Vascular YXYichun XuShanghai Jiao Tong University SBStéphane BlotInserm

Discussion

Member takes

Implication

Hypothesis-generating in L-NAME rat model; leaves open clinical translation of quinapril benefits.

Structured PICO

Does quinapril improve survival and prevent tissue damage in rats administered L-NAME?

Population

Rats administered NG-nitro L-arginine methyl ester (L-NAME) (50 mg/kg) to induce chronic nitric oxide synthase blockade

Intervention

Quinapril (10 mg/kg) starting 1 month after L-NAME administration

Comparator

L-NAME alone (50 mg/kg) and untreated controls

Outcome

Survival rate, blood pressure, renal function, and tissue morphology (renal and cervical medulla)hard clinical

ACE inhibition with quinapril reverses hypertension and prevents end-stage vascular damage and mortality induced by chronic nitric oxide synthase blockade in rats.

Cite This Study

Michel et al. (1996) studied this question.

synapsesocial.com/papers/6a1a1cf6443d3ecd7cdf5cf7 https://doi.org/10.1097/00005344-199607000-00021

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark