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September 1, 1991Clinical and Experimental Pharmacology and Physiology

NO2Arg administration for 1 week significantly increased systolic blood pressure similarly in SHRSP (21 mmHg) and WKY (23 mmHg) and markedly decreased acetylcholine-induced relaxation to 43-44% of controls.

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Why the study?

Does NG-nitro-L-arginine (NO2Arg) increase blood pressure and inhibit endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats compared to normotensive rats?

Population

Female stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY)

Comparison

NG-nitro-L-arginine administered in food for 1… vs Control rats

Design

Preclinical

Follow-up

1 week

Authors

YKYuta KobayashiKIKatsumi IkedaEKEiichi Kakizoe

Discussion

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Overview

NO contributes to BP regulation despite hypertension in rats; leaves open translation to human endothelial therapies.

Structured PICO

Does NG-nitro-L-arginine (NO2Arg) increase blood pressure and inhibit endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats compared to normotensive rats?

P
Population
Female stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY)
I
Intervention
NG-nitro-L-arginine (NO2Arg) administered in food (0.023% in weight, about 2.8 mg/rat per day) for 1 week
C
Comparator
Control rats
O
Outcome
Systolic blood pressure and endothelium-dependent vascular relaxation (acetylcholine-induced relaxation in thoracic aorta)surrogate

Endothelium-dependent relaxation contributes to blood pressure regulation in the hypertensive state, despite a baseline decline in this relaxation in stroke-prone spontaneously hypertensive rats.

Cite This Study

Kobayashi et al. (1991) studied this question.

synapsesocial.com/papers/6a9808e2883af1d6c8a6904fhttps://doi.org/10.1111/j.1440-1681.1991.tb01632.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1L‐NITROARGININE INCREASES BLOOD PRESSURE IN THE RAT1991 · 23 citations
  2. 2Increased vascular responsiveness to bradykinin in kidneys of spontaneously hypertensive rats. Effect of N omega-nitro-L-arginine.1991 · 58 citations
  3. 3Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats1997 · 44 citations
  4. 4Effect of Oral L-Arginine Administration for Three Weeks in Two Kidney-two Clip Hypertensive Rats2000 · 12 citations
  5. 5EFFECTS OF NITRIC OXIDE SYNTHASE INHIBITION AND ENDOTHELIN ET<sub>A</sub> RECEPTOR BLOCKADE ON HAEMODYNAMICS IN HYPERTENSIVE RATS1998 · 8 citations